Different from the dike break of general rivers for discharging flood, the outburst flood from high-filled reaches of large-scale artificial water supply channel under supernormal external force would cause extrinsic catastrophic impacts on the outside area. In order to prevent this potential risk which is hard to be characterized using probability, scenario analysis method is needed to simulate and evaluate the effectiveness of combined application of various control measures under different breach scale in emergency disposal. Based on the existing flooding and water-logging simulation model developed independently by China Institute of Water Resources and Hydropower Research, the topological relation of calculation unit for crossed channels and simulation method for recession sluices were improved. A synchronous coupled dike-breaking flood inundation simulation model with one-dimensional model in channel, breach discharge calculation and two-dimensional model in both banks area of channel was built. Take a typical high-filled reaches of a large-scale artificial water supply channel as example, the change of flood inundation characteristic value was analyzed for 12 scenarios with different breach width, closing time for sluice gates and whether recession sluices were used. The results showed that the increase of breach width had less impact on inundation extent and degree of outburst flood; the earlier the closure time of sluice gates was, the better the decrease of inundation area and water depth was, and the effect was more obvious during the first 3 hours after dike-breaking happened; when the terrain and ground objects distribution were conductive to flood diffusion, closing sluice gate early could decrease more inundation area, otherwise, in areas where flood is not easy to spread, it was more effective for decrease of inundation depth; the mitigation function of recession sluice for inundation was relevant to the relative position and distance between the gate and breach, the sluice located in the upper stream of breach with closer distance was more effective to decrease the inundation. This study can provide basic method and basis for the formulation or improvement of corresponding emergency plans of large-scale artificial water supply channel.