Water resources are the basic strategic resources for regional economic and social development, and the spatial balance of regional water use efficiency (WUE) is the prerequisite and inevitable requirement for balanced and coordinated development of region. In view of the unbalanced problem of regional WUE, this paper studied the characteristic of the spatiotemporal evolution of regional WUE and its spatial correlation degree by constructing gravity model combined with ArcGIS spatial analysis technique, and investigated the influencing factors using the multiple regression analysis method. Taking Guangdong province as an example, 21 prefecture-level cities panel data from 2004 to 2018 were calculated and analyzed. The results show that：Both the water consumption per ten thousand yuan of GDP and the average water consumption per mu for farmland irrigation have strong spatial correlations in Guangdong province. The Pearl River Delta (PRD) is an area with high WUE, while the north of Guangdong and the east and west sides are areas with low WUE; The correlation degree of WUE in the whole province showed an increasing trend over time. The gravity value of WUE was the strongest in the PRD, followed by that in the east of the province, and weaker in the north and west of the province; The impact of research and experimental development funds on the potential of WUE correlation is more lasting and is the main driving factor. This study puts forward countermeasures and suggestions mainly from the aspects of giving full play to the linkage effect of high WUE in the PRD and increasing investment in water conservancy science and technology innovation, and can provide theoretical basis and reference for the spatial equilibrium of regional WUE.